职称：研究员
研究方向：运动控制、空间导航、语音交流及相关疾病的神经机制/脑机接口
Email：lxjbio@fyust.edu.cn
李新建，1977年8月生，河南人，博士生导师。2009年毕业于中国科学院神经科学研究所，获博士学位。2011—2018年先后在香港理工大学、美国约翰斯·霍普金斯大学（Johns Hopkins University）和美国国立卫生研究院（National Institutes of Health, NIH）从事博士后研究。2019年加入浙江大学及浙江大学医学院，2026年加入福耀科技大学。李新建教授长期从事运动控制、空间导航、脑机接口、语言与社会交流及运动相关疾病神经机制研究。课题组以小鼠和非人灵长类动物狨猴为主要模式动物，综合运用在体钙成像、多通道电生理、神经环路操控及脑机接口等技术，在自由活动和自然行为状态下解析大规模神经元群体活动，重点研究大脑如何编码运动、空间及复杂行为信息，以及不同脑区和神经环路之间的信息交互与计算机制。近年来，李新建教授已在神经科学及相关交叉领域发表学术论文30余篇，代表性成果发表于 Nature、Cell、Nature Neuroscience、Advanced Science、National Science Review、Nature Communications、eLife、Communications Biology、NeuroImage、The Journal of Physiology、Advanced Materials、Molecular Psychiatry、Cerebral Cortex、Sleep 和 Journal of Neuroscience Methods 等核心期刊。科研项目方面，李新建教授先后主持国家自然科学基金面上项目2项，并作为课题负责人承担科技部“智能机器人”重点专项相关课题，同时参与科技创新2030—“脑科学与类脑研究”重大项目。课题组致力于推动神经科学、脑机接口与人工智能等领域的交叉融合，探索从神经机制解析到脑机接口和神经系统疾病诊疗的新技术与新方法。
中国科学院神经科学研究所 神经生物学 研究生 博士
华东师范大学 生理学 研究生 硕士
河南师范大学 生物学教育 本科 学士
本课题组主要研究运动控制、空间导航、语音交流及相关脑功能疾病的神经机制。运动是动物及人类适应环境和生存的重要基础，但大脑如何在自然行为状态下编码个体的运动与空间信息，以及如何通过神经环路整合多维感知与运动信息，仍缺乏系统认识。课题组以自由活动动物中的大规模单细胞神经活动记录为重要技术突破，综合运用脑成像、多通道电生理、神经环路解析及神经调控等技术，研究大脑在复杂三维环境中的运动编码、空间导航及行为决策机制，并进一步探索高级脑功能与神经系统疾病的神经基础。在基础研究的基础上，课题组致力于推动神经科学与工程技术的交叉融合，发展脑机接口、神经调控及神经疾病诊疗新技术，实现从神经机制解析到脑功能调控与临床转化的贯通。
1. Runze Qi, Yingxu Lin, Shanshan Liu, Xinyuan Cao, Min Xie, Chencen Yu, Hao Sun, Lixia Gao# and Xinjian Li#, Vocal taking turns is premature at birth and improved by the postnatal phonetic environment in marmosets, National Science Review, 2025 Apr 24;12(7):nwaf162. doi: 10.1093/nsr/nwaf162. PMID: 40636103; PMCID: PMC12239203. Impact factor: 16.3.
2. Chenfei Lyu, Chencen Yu, Guanglong Sun, Yue Zhao, Ruolan Cai, Hao Sun, Xintai Wang, Guoqiang Jia, Lingzhu Fan, Xi Chen, Lin Zhou, Ying Shen#, Lixia Gao# and Xinjian Li#, Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice, Advanced Science. 2022 Nov 14;10(1):e2203665. doi: 10.1002/advs.202203665. Impact factor: 17.521
3. Zhang-Peng Chen#, Xiansen Zhao#, Suji Wang#, Ruolan Cai#, Haojie Ye, Meng-Ju Wang, Shi-Yu Peng, Wei-Xuan Xue, Yang-Xun Zhang, Wei Li, Hua Tang, Tengfei Huang, Qipeng Zhang, Liang Li, Lixia Gao, Hong Zhou, Chunhua Hang, Jing-Ning Zhu, Xinjian Li*, Xiangyu Liu*, Qifei Cong*, Chao Yan*, GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy. Nature Neuroscience, 2025 Jul;28(7):1404-1417. doi: 10.1038/s41593-025-01979-2. Impact factor: 21.3
4. Guoqiang Jia, Siyi Bai, Xiaohui Wang, Lin Zhu, Chenfei Lyu, Guanglong Sun, Anna Wang Roe, Xinjian Li#, Lixia Gao#, Representation of individual conspecific vocalizations in amygdala of awake marmoset, National Science Review, 2023 July 13;10(11):nwad194. Doi: 10.1093/nsr/nwad194. eCollection 2023 Nov. Impact factor: 20.3
5. Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao#, Xinjian Li# and Mingjun Zhang#, Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large-Scale Coverage Neural Recorder, Advanced Science, 2026 Jan;13(2):e07110. doi: 10.1002/advs.202507110，Impact factor: 14.1
6. Guanglong Sun, Chencen Yu, Ruolan Cai, Mingxuan Li, Lingzhu Fan, Hao Sun, Chenfei Lyu, Yingxu Lin, Lixia Gao, Kuan Hong Wang# and Xinjian Li#, Neural Representation of self-initiated locomotion in secondary motor cortex across different spatial contexts, Communications Biology, 2025, May 10;8(1):725. doi: 10.1038/s42003-025-08169-7. Impact factor:5.2
7. YP Yang*, Xinjian Li*, V Stuphorn#, Primate anterior insular cortex represents economic decision variables proposed by prospect theory, Nature Communications 2022 Feb 7;13(1):717. doi: 10.1038/s41467-022-28278-9 (*Co-first author, equal Contribution). Impact factor: 17.694
8. Hao Sun, Ruolan Cai, Rui Li, Mingxuan Li, Lixia Gao, Xinjian Li#, Conjunctive processing of spatial border and locomotion in retrosplenial cortex during spatial navigation, Journal of physiology-London, 2024 Oct;602(19):5017-5038. doi: 10.1113/JP286434. Epub 2024 Aug 31. Impact factor: 4.7
9. Qianbing Li, An Ping, Yuqi Feng, Bin Xu, Baorong Zhang, Anna Wang Roe#, Lixia Gao# and Xinjian Li#, Mesoscale functional connectivity of amygdala to the auditory and prefrontal cortex of macaque monkeys revealed by INS-fMRI, Neuroimage. 2025 Sep; 318:121406. doi: 10.1016/j.neuroimage.2025.121406. Epub 2025 Jul 29. PMID: 40744250. Impact factor: 4.5
10. Xiaohui Wang, Yuanqing Zhang, Lin Zhu, Siyi Bai, Rui Li, Hao Sun, Runze Qi, Ruolan Cai, Min Li, Guoqiang Jia, Xinyuan Cao, Kenneth E. Schriver, Xinjian Li#, Lixia Gao#, Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets, Cerebral Cortex, 2023 March 21; bhac278. doi: 10.1093/cercor/bhac278. Impact factor: 4.861
11. Surjeet Mastwal*, Xinjian Li*, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-jun Yoon, Hongjun Song, Guo-li Ming, Kuan Hong Wang, Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function, 2023 October 13;12:RP87414. doi: 10.7554/eLife.87414., (*Co-first author, equal Contribution). Impact factor: 7.7
12. Guanglong Sun, Chenfei Lyu, Ruolan Cai, Chencen Yu, Hao Sun, Ken E. Schriver, Lixia Gao， and Xinjian Li#， DeepBhvTracking: A Novel Behavior Tracking Method for Laboratory Animals Based on Deep Learning， Frontier in behavior Neuroscience, 2021, October 28 2021 | https://doi.org/10.3389/fnbeh.2021.750894. Impact factor: 3.617
13. Liu Y*, Latremoliere A*, Li Xinjian*, Zhang Z*, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 Sep;561(7724):547-550. (*Co-first author, equal Contribution). Impact factor：69.504
14. Xuhua Wang*, Yuanyuan Liu*, Xinjian Li*, Zicong Zhang*, Hengfu Yang, Yu Zhang, Philip R. Williams, Noaf S. A. Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R. Gerfen, Kuan Hong Wang, Zhigang He, Deconstruction of corticospinal circuits for goal-directed motor skills, Cell 171, 1–16, October 5, 2017 ª, (*Co-first author, equal Contribution). Impact factor: 66.85
15. Li Xinjian, Cao VY, Zhang W, Mastwal SS, Liu Q, Otte S, Wang KH. Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes, J Neurosci Methods. 2017 August 19. pii: S0165-0270(17)30297-2. Impact factor: 2.987
16. Xinjian Li, Feng Yu, Aike Guo, Sleep deprivation specifically impairs short-term olfactory memory in Drosophila. Sleep, November 1, 2009; 32(11): 1417-24. Impact factor: 6.313
17. Cao K, Tian Y, Zheng K, Xi W, Xinjian Li, Chen Liangjun Spontaneous Yet Predictable: Shapelet-Driven, Channel-Aware Intention Decoding from Multi-Region ECoG. Proceedings of the AAAI Conference on Artificial Intelligence 2026 Mar 14 (Vol. 40, No. 21, pp. 17384-17392).
18. Siyi Bai, Xinyuan Cao, Min Xie, Guanglong Sun, Xiaohui Wang, Leilei Zheng, Xinjian Li, Zheng Lin & Lixia Gao. Acoustic Flutter Processing in the Inferior Colliculus of Awake Marmosets: Complementary Rate Coding Modulated by Acoustic Parameters. Neurosci. Bull. (2026). https://doi.org/10.1007/s12264-026-01587-5，Impact factor: 5.9
19. Yuwen Chen, Haoyu Yang, Yan Luo, Yijun Niu, Muzhou Yu, Shanjun Deng, Xuanhao Wang, Handi Deng, Haichao Chen, Lixia Gao, Xinjian Li, Pingyong Xu, Fudong Xue, Jing Miao, Song-Hai Shi, Yi Zhong, Cheng Ma & Bo Lei, Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain, Nature Communications. 2024 May 18;15(1):4228. doi: 10.1038/s41467-024-48393-z. Impact factor: 14.7
20. Sun Hao, Li Rui, Lin Yingxu, Cao Xinyuan, Fan Lingzhu, Sun Guanglong, Xie Min, Zhu Lin, Yu Chenchen, Cai Ruolan, Lyu Chenfei, Wang Xiaohui, Zhang Yuanqing, Bai Siyi, Qi Runze, Tang Bingliang, Jia Guoqiang, Li Xinjian, Gao Lixia. Hand-Rearing Method for Infant Marmosets. J Vis Exp. 2023 Jun 9;(196). doi: 10.3791/65296. PMID: 37358299. Impact factor: 1.2
21. Lin Zhu, Di Zheng, Rui Li, Chen-Jie Shen, Ruolan Cai, Hao Sun, Xiaohui Wang, Yu Ding, Bin Xu, Guoqiang Jia, Xinjian Li, Lixia Gao, Xiao-Ming Li, Induction of Anxiety-Like Phenotypes by Knockout of Cannabinoid Type-1 Receptor in Amygdala of Marmosets, Neuroscience Bulletin, 2023 June 27. doi: 10.1007/s12264-023-01081-2. Impact factor: 5.3
22. Xinyuan Cao, Lin Zhu, Runze Qi, Xiaohui Wang, Guanglong Sun, Yue Ying, Ruixue Chen, Xinjian Li, Lixia Gao*, Effect of a High Estrogen Level in Early Pregnancy on the Development and Behavior of Marmoset Offspring, ACS Omega, https://doi.org/10.1021/acsomega.2c03263. Impact factor: 4.132
23. Shuhao Qian, Jia Meng, Zhe Feng, Lingxi Zhou, Shenyi Jiang, Yalun Wang, Zitong Ye, Shuangmu Zhuo, Jianxin Chen, Xinjian Li, Lixia Gao, Zhihua Ding, Jun Qian, Zhiyi Liu, Mapping Organizational Changes of Fiber‐Like Structures in Disease Progression by Multiparametric, Quantitative Imaging, Laser & Photonics Reviews, Vol. 16|June 2022, https://doi.org/10.1002/lpor.202270029. Impact factor: 10.947
24. J Meng, Z Feng, S Qian, C Wang, Xinjian Li, L Gao, Z Ding, J Qian, Z Liu, Mapping physiological and pathological functions of cortical vasculature through aggregation-induced emission nanoprobes assisted quantitative, in vivo NIR-II imaging, Biomaterials Advances, Volume 136, May 2022, 212760. Impact factor: 7.328
25. Xiaohui Wang, Yuanqing Zhang, Siyi Bai, Runze Qi, Hao Sun, Rui Li, Lin Zhu, Xinyuan Cao, Guoqiang Jia, Xinjian Li, Lixia Gao, Corticofugal Modulation of Temporal and Rate Representations in the Inferior Colliculus of the Awake Marmoset, Cereb Cortex. 2022 January 4;bhab467. doi: 10.1093/cercor/bhab467. Impact factor: 4.861
26. Zhe Feng, Siyi Bai, Ji Qi, Chaowei Sun, Yuhuang Zhang, Xiaoming Yu, Huwei Ni, Di Wu, Xiaoxiao Fan, Dingwei Xue, Shunjie Liu, Ming Chen, Junyi Gong, Peifa Wei, Mubin He, Jacky W. Y. Lam, Xinjian Li, Ben Zhong Tang, Lixia Gao, and Jun Qian, Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine, Advanced Materials 2021 March 19; e2008123. Doi: 10.1002/adma.202008123. Impact factor: 32.086
27. Li Sun, Rui Liu, Fang Guo, Man-qing Wen, Xiao-lin Ma, Kai yuan Li, Hao Sun, Cenglin Xu, Yuan-yuan Li, Mengyin Wu, Zhenggang Zhu, Xinjian Li, Yan-qin Yu, Zhong Chen, Xiangyao Li, and Shumin Duan, Parabrachial nucleus circuit governs neuropathic pain-like behavior, Nature communications, 2020 November 25;11(1):5974. doi: 10.1038/s41467-020-19767-w. Impact factor: 17.694
28. Jia G, Li Xinjian, Liu C, He J, Gao L. Stimulus-Specific Adaptation in Auditory Thalamus Is Modulated by the Thalamic Reticular Nucleus, ACS Chem Neuros. 2021 May 5;12(9):1688-1697. doi: 10.1021/acschemneuro.1c00137. Epub 2021 April 26. Impact factor: 5.78
29. Gao L, Zhang Y, Li Xinjian, He J. Enhancement of Neuronal Activity in the Auditory Thalamus After Simulated Slow-Wave Oscillation, Neurosci Bull. 2020 Jul;36(7):806-810. doi: 10.1007/s12264-020-00487-6. Epub 2020 March 21. Impact factor: 5.271
30. Ren M, Hu Z, Chen Q, Jaffe A, Li Y, Sadashivaiah V, Zhu S, Rajpurohit N， Heon Shin J, Xia W, Jia Y, Wu J, Lang Qin S, Li Xinjian, et al. KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. Mol Psychiatry. 2019 September 30. Impact factor: 13.437
31. Gao L, Li Xinjian, Yang W, Sun X, Modulation of azimuth tuning plasticity in rat primary auditory cortex by medial prefrontal cortex. Neuroscience. 2017 April 7; 347:36-47. Impact factor: 3.708
32. Chen X, Guo Y, Feng J, Liao Z, Li Xinjian, Wang H, Li X, He J, Encoding and retrieval of artificial visuoauditory memory traces in the auditory cortex requires the entorhinal cortex. J Neurosci. 2013 Jun 12; 33(24):9963-74. 5.673. Impact factor: 6.709
33. 李先春,李新建. 中枢神经系统中的视听整合作用，生物学教学, 2003, 28(08)
1. 科技部，科技创新 2030—“脑科学与类脑研究”重大项目，2022ZD0205000，认知地图的神经机制，2022-08-25 至 2027-08-24， 4900万（个人经费，296万），进行中，项目骨干
2. 科技部，国家重点研发智能机器人专项，2023YFB4705500，基于脑机智能融合的行为增强理论与方法，2024-12-1至2027-11-30，580万（个人经费，78万），进行中，子课题负责人
3. 国家自然科学基金委员会，国家自然科学基金面上项目，32371074，小脑在空间导航中的功能及神经环路研究，2024-1-1至2027-12-30，50万元，进行中，主持
4. 国家自然科学基金委员会，国家自然科学基金面上项目，32071097，压后皮层在空间导航中的功能及神经机制研究，2021-1-1至2025-12-30，58万元，结题，主持
5. 浙江大学教育部，脑与脑机融合项目，自由活动动物的运动和非运动行为的小脑神经编码研究，2021-1-1至2023-12-30，60万元，结题，主持
6. 浙江省自然科学基金，浙江省自然科学基金重大项目，LD22H090003，抑郁症非人灵长类模型的建立及神经环路研究，2021-1-1至2023-12-30， 100万元（个人经费，30万元），结题，参与
7. 南京超微景，南京脑观象台探索计划，自由活动动物的运动行为的小脑神经编码研究，2021-1-1至2023-12-1，15万元，结题，主持
1. 高利霞; 贾国强; 李新建; 李瑞; 孙昊; 一种人工喂养新生狨猴的方法，2022-10-14至2041-08-23, 中国，CN 113615641 B
2. 高利霞; 孙昊; 李新建; 李瑞; 一种实验动物行为学三维数据记录方法，2023-07-18至2042-03-28, 中国，CN202210316172.4.
3. 高利霞; 李倩冰; 李新建; 王晓会; 谢敏; 一种非人灵长类动物孤独症模型的构建方法，2024-11-12至2044-03-14, 中国，CN202410291497.0
