美国乔治城大学  生理与生物物理学  博士

中南大学湘雅医学院  临床医学  学士

聚焦神经肽信号通路及肿瘤微环境，探索神经系统肿瘤发生发展的分子机制及精准治疗新靶点。

开发基于CRISPR的功能筛选平台，解析神经发育、精神疾病及肿瘤发生发展的关键调控网络。

研究干细胞向功能性神经元分化的分子调控机制，探索神经再生与细胞治疗的新策略。

1. Congyi Lu*, GörkemGaripler*, Chao Dai*, Timothy Roush, Jose Salome-Correa, Alex Martin, Noa Liscovitch-Brauer, Esteban O. Mazzoni, Neville E. Sanjana. Essential transcription factors for induced neuron differentiation. Nature Communications, 2023 Dec 15;14(1):8362.

2. Xi Shi*, Congyi Lu*, Alba Corman*, Alexandra Nikish, Yang Zhou, Randy J. Platt, Ivan Iossifov, Feng Zhang, Jen Q. Pan, Neville E. Sanjana. Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction. The American Journal of Human Genetics, 2023 Oct 5;110(10):1750-1768

3. Congyi Lu*, Akanksha Mahajan*, Sung-Hyeok Hong*, Susana Galli, Shiya Zhu, Jason U. Tilan, Nouran Abualsaud, Mina Adnani, Stacey Chung, Nada Elmansy, Jasmine Rodgers, Olga Rodriguez, Christopher Albanese, Hongkun Wang, Maureen Regan, Valerie Zgonc, Jan Blancato, Ewa Krawczyk, G. Ian Gallicano, Michael Girgis, Amrita Cheema, Ewa Iżycka-Świeszewska, Luciane R. Cavalli, Svetlana D. Pack, Joanna Kitlinska. Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma. Nature Communications, 2022 Apr 28;13(1):2323

3. Gorkem Garipler*, Congyi Lu*, Alexis Morrissey, Lorena S. Lopez-Zepeda, Yingzhen Pei, Simon E. Vidal, Ana Paula Zen Petisco Fiore, Begum Aydin, Matthias Stadtfeld, Uwe Ohler, Shaun Mahony, Neville E. Sanjana, Esteban O. Mazzoni. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. Cell Reports, 2022 Mar 15;38(11):110524

5. Congi Lu, Neville E. Sanjana. Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A). Stem Cell Research, 2019 Nov 1

6. Congyi Lu*, Xi Shi*, Andrew Allen, David Baez-Nieto, Alexandria Nikish, Neville E. Sanjana, Jen Q. Pan. Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. FASEB Journal, 2019 Apr 1

7. Congyi Lu, Qian Chen, Tom Zhou, Denis Bozic, Zhanyan Fu, Jen Pan, Guoping Feng, Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Molecular Psychiatry, 2016 Feb;21(2):159-68

8. Jason U. Tilan*, Congyi Lu*, Susana Galli, Ewa Izycka-Swieszewska, Joshua Patrick Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O’Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson,

Jeffrey A. Toretsky, Joanna Kitlinska. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget, 2013 Dec;4(12):2487-501

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9. Congyi Lu, Jason U. Tilan, Lindsay Everhart, Magdalena Czarnecka, Steven J. Soldin, Damodara R. Mendu, Dima Jeha, Jailan Hanafy, Christina K. Lee, Junfeng Sun, Ewa Izycka-Swieszewska, Jeffrey A. Toretsky, Joanna Kitlinska. Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. Journal of Biological Chemistry, 2011 Aug 5;286(31):27494-505.

10. Congyi Lu, Lindsay Everhart, Jason U. Tilan, Lydia Kuo, CC Sun, RB Munivenkatappa, AC Jönsson-

Rylander, Junfeng Sun, Ana Kuan-Celarier, L Li, K Abe, Zofia Zukowska, Jeffrey A. Toretsky, Joanna Kitlinska. Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy. Oncogene, 2010 Oct 14;29(41):5630-42.

11. Congyi Lu, Zhanyan Fu, Irina Karavanov, Robert P. Yasuda, Barry B. Wolfe, Andres Buonanno, Stefano Vicini. NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons. Journal of Neurophysiology, 2006 Nov;96(5):2282-94.