香港大学 化学系 理学博士

上海交通大学 药学院 理学学士

致力于小分子药物多靶点药理机制的信息化，推动高维生物数据驱动的交叉研究。基于配位化学原理，使用化学多组学、计算机模拟及数学方法，构建融合生物信息的“干湿结合”小分子药效靶点发现平台，并围绕平台开展一系列新药、组学技术和生物信息学算法开发。特别专注于天然产物小分子与细胞坏死、炎症及免疫相关金属蛋白的相互作用及药理机制研究。利用天然产物小分子多样性及传统用药经验，以高维生物数据和统计推断算法融合“病症-药物-靶点”信息，系统性开发针对中风、心梗、炎症风暴、炎症性肠病和神经退行性疾病等临床病症的特效药，特别专注于脑疾病药物开发以及脑部给药方法研究。

1. Jiang H, Hu X, Zheng L*, Hong Y*. (2025) ALKBH7 mediates the mitigative effect of bismuth against cisplatin induced acute kidney injury. Biochem Pharmacol 239:117045.

2. Hong Y†*, Ye T†, Jiang H†, Wang A, Wang B, Li Y, Xie H, Meng H, Shen C*, Ding X*. (2025) Panoramic lead-immune system interactome reveals diversified mechanisms of immunotoxicity upon chronic lead exposure. Cell Biol Toxicol 41:81.

3. An H, Hong Y, Goh Y, Koh C, Kanwal S, Zhang Y, Lu Z, Yap P, Neo S, Wong C, Wong A, Yu Y, Ho J, Gunaratne J, Goh W* (2024) m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiation. Mol Cell, 84(21):4142-4157.

4. Jiang H, Gao Y, Chen X, Wang B, Xu Z, Li Y, Sun X, Liu K, Divsalar A, Cheung E, Jiang L, Hong Y*, Ding X*. (2024) Single-Cell study Unveils Lead Lifespan in Blood Cell Populations Follows a Universal Lognormal Distribution with Individual Skewness, Anal Chem, 96: 668-675.

5. Zheng T†, Liu H†, Hong Y†, Cao Y, Xia Q, Qin C, Li M, Reiter R, Bai Y, and Fan L*. (2023) Promotion of liquid-to-solid phase transition of cGAS by baicalein suppresses lung tumorigenesis. Signal Transduct Target Ther 8:133.

6. Li C, Zhang Y, Xia Q, Hao B, Hong Y, Yue L, Zheng T, Li M, Fan L* (2023) Multi-omics analysis revealed the mitochondrial-targeted drug combination to suppress the development of lung cancer. J Cancer Res Clin 149(19):17159-17174.

7. Jiang H†, Hong Y†*, Fan G*. (2022) Bismuth reduces cisplatin-induced nephrotoxicity via enhancing glutathione conjugation and vesicular transport. Front Pharmacol 13:887876.

8. Hu X, Li F, Zeng J, Zhou Z, Wang Z, Chen J, Cao D, Hong Y, Huang L, Chen Y, Xu J, Dong F, Yu R, Zheng H* (2022) Noninvasive Low-Frequency Pulsed Focused Ultrasound Therapy for Rheumatoid Arthritis in Mice, Research 2022(0013).

9. 洪祎璠; 质谱流式数据综合分析软件Athena V1.0, 2023SR0193174, 原始取得, 全部权利, 2021-11-28.

10. Li Y, An H, Shen C, Wang B, Zhang T, Hong Y, Jiang H, Zhou P, Ding X*. (2021) Deep phenotyping of T cell populations under long-term treatment of tacrolimus and rapamycin in patients receiving renal transplantations by mass cytometry. Clin Transl Med 11(11).

11. Meng H, Warden A, Zhang L, Zhang T, Li Y, Tan Z, Wang B, Li H, Jiang H, Shen G, Hong Y, Ding X*. (2019) A Mass-ratiometry-based CD45 barcoding method for mass cytometry detection. SLAS technol:2472630319834057.

12. Hong Y, Lai YT, Chan GC, Sun H* (2015) Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells. Proc Natl Acad Sci USA 112(11):3211-3216.

This article was highlight and commentary was invited by PNAS:

· Selective action of heavy metal drugs on pathogens

· Romero-Canelon I & Sadler PJ (2015) Systems approach to metal-based pharmacology. Proc Natl Acad Sci USA 112(14):4187-4188.

1. 国家自然科学基金委员会, 青年科学基金, 31900633, 基于质谱流式的抗幽门螺杆菌药铋剂的免疫药理研究, 2020-01-01 至 2022-12-31, 25万元, 结题, 主持

2. 上海市科学技术委员会, 港澳台科技合作, 18430760500, 基于质谱流式技术的肠道药物代谢酶及转运蛋白机制研究, 2018-09 至 2021-08, 40万元, 结题, 参与

3. 中华人民共和国科学技术部, 重大专项, SQ2017ZX100203, 乙肝相关肝癌肝移植临床诊疗新体系研究及应用推广, 2017-01 至 2020-12, 57万元, 结题, 参与

4. 上海市科学技术委员会, 一般, 17DZ2203400, 中药类保健食品绞股蓝的功效性控制标准研究, 2017-07 至 2020-06, 35万元, 结题, 参与

5. 中央军委科学技术委员会, 国防科技创新特区, 18-163-15-LZ-001-002-03, 多因系统动态逻辑及应用研究, 2017-05 至 2017-10, 30万元, 结题, 参与