英国Dundee大学 癌症生物学与化学预防 博士

致力于研发Nrf1靶向药物，激活生命内稳态抵御机制，实现抗氧化、抗炎症、抗衰老、抗癌变;  规划“拓扑定位机器人”项目，旨在破解下一代生命健康科学的巨大挑战。

1.  Yiguo Zhang (corresponding author), Xi Chen, Meng Wang, Yuping Zhu, Wei Shi, Chao Li, Zhengwen Zhang, Hiroaki Taniguchi, Ping Ao. Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories. DOI:10.12074/202405.00265V1 at https://chinaxiv.org/abs/202405.00265; https://doi.org/10.31219/osf.io/xpeq8

2. Reziyamu Wufuer, Keli Liu, Jing Feng, Meng Wang, Shaofan Hu, Feilong Chen, Shanshan Lin, Yiguo Zhang (corresponding author).Distinct mechanisms by which Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of cisplatin on hepatoma cells. Free Radic Biol Med. 2024 Mar;213:488-511. doi: 10.1016/j.freeradbiomed.2024.01.031. bioRxiv, doi:https://doi.org/10.1101/ 2023.08.16.553539

3. Rongzhen Deng, Yuping Zhu, Keli Liu, Qun Zhang, Shaofan Hu, Meng Wang, Yiguo Zhang (corresponding author).Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway. Bioorg Chem. 2024 Apr;145:107212. doi: 10.1016/j.bioorg.2024.107212.

4. Kamila Łuczyńska, Zhengwen Zhang, Tadeusz Pietras, Yiguo Zhang (corresponding author)Hiroaki Taniguchi. NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases. Redox Biol. 2024 Feb;69:103003. doi: 10.1016/j.redox. 2023.103003

5. Feilong Chen,  Qing Wang, Mei Xiao, Deshuai Lou, Reziyamu Wufur, Shaofan Hu, Zhengwen Zhang, Yeqi Wang, Yiguo Zhang (corresponding author). A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors. Free Radic Biol Med. 2024 Mar;213:190-207. doi: 10.1016/j.freeradbiomed.2024.01.025. Epub 2024 Jan 17.PMID: 38242246 bioRxiv, doi:https://doi.org/10.1101/2022.11.22.517594

6. Qiqi Bu, Yangxu Deng, Qing Wang, Rongzhen Deng, Shaofan Hu, Zhigang Pei, Yiguo Zhang (corresponding author). STC2 is a potential biomarker of hepatocellular carcinoma with its expression being upregulated in Nrf1α-deficient cells, but downregulated in Nrf2-deficient cells. Int J Biol Macromol. 2023 Dec 31;253(Pt 8):127575. doi: 10.1016/j.ijbiomac.2023.127575. bioRxiv 2023.05.15.540796; doi: https://doi.org/10.1101/2023.05.15.540796

7. Shaofan Hu, Jing Feng, Meng Wang, Reziyamu Wufuer, Keli Liu, Zhengwen Zhang,  Yiguo Zhang (corresponding author).  Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks. Redox Biol. 2022 Sep 13;57:102470. doi: 10.1016/j.redox.2022.102470. bioRxiv, doi:https://doi.org/10.1101/2021.11.29.470338

8. Yu-Ping Zhu, Yuancai Xiang, Aurore L'honoré, Didier Montarras, Margaret Buckingham, Yiguo Zhang (corresponding author) (2020) Commentary on Distinct, but Previously Confused, Nrf1 Transcription Factors and Their Functions in Redox Regulation. Dev Cell. 2020 May 18;53(4):377-378. doi: 10.1016/j.devcel.2020.04.022

9. Rongzhen Deng, Ze Zheng, Meng Wang, Shaofan Hu, Jing Feng, Yiguo Zhang Yiguo Zhang (corresponding author) Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate. Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119644. doi: 10.1016/ j.bbamcr.2023.119644 bioRxiv 2021.09.29.462358; doi: https://doi.org/10.1101/2021.09.29.462358

10. Shaofan Hu, Yuancai Xiang, Lu Qiu, Meng Wang, Yiguo Zhang (corresponding author). Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally tail-anchored in the endoplasmic reticulum. Biochim Biophys Acta Mol Cell Res. 2022 May 22;1869(9):119299.doi:10.1016 /j.bba mcr. 2022.119299. bioRxiv 2020.10.05.326363. doi: https://doi.org/10.1101/2020.10.05.326363

    
    

1. 国家自然科学基金委面上项目：跨膜转录因子Nrf1α/TCF11靶向激活内稳态保护机制而预防炎-癌转化的新策略研究，2025.01 - 2028.12；

   
   

2. 国家自然科学基金委面上项目：Nrf1/2介导氧化还原信号-代谢-靶基因关联细胞器互作网络差异调控炎症-癌症及其病理转化的机制研究，2021.01 - 2024.12；