职称：副教授/研究员
研究方向：阿尔茨海默病发病机制与干预治疗
Email：zhengwu@fyust.edu.cn
1982年12月出生，安徽人，博士毕业于复旦大学神经生物学专业。2011年8月至2016年7月在美国宾夕法尼亚州立大学从事博士后研究，随后留校担任研究型助理教授。2020年9月全职回国，加入暨南大学粤港澳中枢神经再生研究院，随后获得广东省“珠江人才计划”青年拔尖人才称号。2026年9月全职加入福耀科技大学生命与健康学院，任副教授/研究员。课题组长期聚焦中枢神经系统疾病的发病机制与干预治疗，尤其关注GABA能神经传导失调在相关疾病中的作用。研究成果以第一/通讯作者发表于Nature Communications、Advanced Science、Molecular Neurodegeneration、APSB等知名期刊。Google学术显示总引用次数超过3000次，其中近五年被引超过1700次，h指数18，i10指数22。作为共同发明人已获授权发明专利12项，部分已进入临床试验阶段。此外，担任Molecular Neurodegeneration、Science Advances、Acta Pharmacologica Sinica、Advanced Science等SCI期刊的同行审稿人，以及NPT杂志青年编委。多次受邀参与国家和省部级项目评审工作。主持和参与的研究项目包括国家自然科学基金面上项目、“珠江人才计划”青年拔尖人才、“珠江人才计划”创新创业团队、广东省自然科学基金面上项目、广州市重点研发计划等。
复旦大学 神经生物学 博士
安徽医科大学 生理学 硕士
安徽医科大学 生物技术 学士
课题组长期致力于阿尔茨海默病（AD）中GABA能神经元功能异常与丢失的机制研究，并探索相应的干预治疗策略。目前，我们聚焦于表达小清蛋白的一类抑制性神经元（PV神经元），发现其功能活性在AD模型小鼠海马显著下降。一方面，反应性星形胶质细胞通过异常释放抑制性递质GABA，对PV神经元施加持续强直性抑制，导致神经网络高频振荡瓦解和认知受损；另一方面，APOE4在PV神经元内表达可引发异常的RNA可变剪切事件，产生异常抗原并诱发自身免疫攻击，造成PV神经元特异性丢失。这两条通路共同揭示了GABA能神经元从功能抑制到结构性丢失的病理进程。基于此，我们致力于解析“星形胶质细胞异常GABA信号—PV神经元功能障碍/丢失—网络节律紊乱—认知衰退”的核心致病轴，并发展精准靶向该通路的干预策略，为AD治疗提供新途径。
1. Chuying Lai, Kaiyu Hou, Wenyu Li, Jiahui Wang, Xiaoman Cai, Ya Shi, Miao Yang, Danting Yu, Kang Lu, Wen Li, Gong Chen*, Zheng Wu*. Olig2 acts as an inducible barrier to in vivo astrocyte-to-neuron conversion. Nature Communications, 2026, Jan 26;17(1):2033.
2. Yaowei Guo, Jiehao Huang, Yuqi Zhang, Yuxiang Huang, Zeru Li, Yu Xie, Yingqi Cao, Kun Qian, Fan Bai, Wen Li, Wenliang Lei*, Gong Chen*, Zheng Wu*. Attenuating AAV-triggered innate immunity in the adult mouse nervous system via cGAS–STING pathway inhibition. Acta Pharmaceutica Sinica B, 2026, April 5.
3. Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu*, Gong Chen*, Wenliang Lei*. A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease-Like Non-Human Primate Model. Advanced Science, 2026, Mar 10:e20239.
4. Zheng Wu*, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen*. Brain-Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease. Advanced Science, 2025, Apr;12(14):e2410080.
5. Zheng Wu*. 40 Hz Gamma Frequency Stimulation in Alzheimer’s Disease: A Promising Non-Invasive Therapy (Research highlight). Neuropharmacology and Therapy, 2025, 2:63-65.
6. Yuge Xu, Xiaoni Bai, Jianhua Lin, Kang Lu, Shihan Weng, Yiying Wu, Shanggong Liu, Houlin Li, Zheng Wu, Gong Chen, Wen Li. Intracranial AAV administration dose-dependently recruits B cells to inhibit the AAV redosing. Molecular Therapy-M&CD, 2025, 33: 1.
7. Xiaosong He, Xin Wang, Hui Wang, Tao Wang, Fuhan Yang, Yuchen Chen, Zifei Pei, Yuting Bai, Wen Li, Zheng Wu, Gong Chen. Neurod1 regulated endothelial gene expression to modulate transduction of AAV-PHP.eB and recovery progress after ischemic stroke. Aging and Disease, 2023, 14:6.
8. Yaowei Guo, Junliang Chen, Wenyu Ji, Liang Xu, Yu Xie, Shu He, Chuying Lai, Kaiyu Hou, Zeru Li, Gong Chen*, Zheng Wu*. High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain. Molecular Therapy-M&CD, 2023, 31: 1011102.
9. Hui Wang, Liang Xu, Chuying Lai, Kaiyu Hou, Junliang Chen, Yaowei Guo, Abhijeet Sambangi, Shreya Swaminathan, Chunming Xie*, Zheng Wu*, Gong Chen*. (2021) Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord. Molecular Brain. 2021 Feb 17;14(1):36.
10. Zheng Wu, Matthew Parry, Xiao-Yi Hou, Min-Hui Liu, Hui Wang, Rachel Cain, Zi-Fei Pei, Yu-Chen Chen, Zi-Yuan Guo, Sambangi Abhijeet, Gong Chen. （2020）Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease. Nature Communications. Feb 27, 2020.
11. Yu-Chen Chen, Ning-Xin Ma, Zi-Fei Pei, Zheng Wu, Fabricio H Do-Monte, Susan Keefe, Emma Yellin, Miranda S Chen, Jiu-Chao Yin, Grace Lee, Angélica Minier-Toribio, Yi Hu, Yu-Ting Bai, Kathryn Lee, Gregory J Quirk, Gong Chen. (2020) A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion. Molecular Therapy. Jan 8, 2020.
12. Zheng Wu*, QW Huo*, L Ren, FP Dong, MY Feng, Y Wang, YT Bai, B Lüscher, ST Li, GL Wang, C Long, Y Wang, G Chen. (2019) Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. Molecular Brain. 2019, 15; 12(1):50.
13. DY Jiang, Zheng Wu, CT Forsyth, Y Hu, SP Yee, G Chen. (2018) GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation. Molecular Brain. 2018, 11 (1), 31.
14. Y Wang, Zheng Wu*, YT Bai, GY Wu*, G Chen*. (2017) Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease. Molecular Neurodegeneration. 2017, 12:73.
15. L Chen, L Wan, Zheng Wu, W Ren, Y Huang, B Qian, Y Wang. (2017) KCC2 downregulation facilitates epileptic seizures. Scientific Reports. Dec; 7(1):156.
16. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Zheng, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G. (2016) KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. Jan 19; 113(3):751-6.
17. Zheng Wu, Alan C. Foster, Ursula Staubli, Xia Wu, Chicheng Sun, Xin Tang, Yong-Xin Li, Gong Chen. (2015) Effects of 3-aminoglutarate, a “silent” false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity. Neuropharmacology. Oct; 97:95-103.
18. Zheng Wu, Ziyuan Guo, Marla Gearing, Gong Chen. (2014) Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model. Nature Communications. June 13, 2014.
19. Wan L, Liu X, Wu Zheng, Ren W, Kong S, Dargham RA, Cheng L, Wang Y. (2014) Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons. Neuroscience Bullet. Oct; 30(5):866-76.
20. Guo Z, Zhang L, Wu Zheng, Chen Y, Wang F, Chen G. (2014) In Vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s Disease model. Cell Stem Cell. 14(2):188-202.
21. Wu X*, Huang L*, Wu Zheng, Zhang C, Jiang D, Bai Y, Wang Y, Chen G. (2013) Homeostatic competition between phasic and tonic inhibition. J Biol Chem. 288(35):25053-65.
22. Yajie Sun*, Zheng Wu*, Shuzhen Kong, Dongyun Jiang, Anar Pitre, Yun Wang, and Gong Chen. (2013) Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors. Molecular Brain. 6:21.
23. Wu X, Wu Zheng, Ning G, Guo Y, Ali R, Macdonald RL, De Blas AL, Luscher B, Chen G. (2012) gamma-Aminobutyric Acid Type A (GABAA) Receptor Alpha Subunits Play a Direct Role in Synaptic versus Extrasynaptic Targeting. J Biol Chem. 287(33): 27417-27430.
24. Qian B, Sun Y, Wu Zheng, Wan L, Chen L, Kong S, Zhang B, Zhang F, Wang ZY, Wang Y. (2011) Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats. Seizure. 20(4):312-9.
25. Chen CR, Tan R, Qu WM, Wu Zheng, Wang Y, Urade Y, Huang ZL. (2011) Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts anti-epileptic effects via GABA-benzodiazepine receptor complex in mice, British Journal of Pharmacology. 164(5):1534-46.
26. Zheng Wu*, Qi Xu*, Liecheng Wang, et al. (2009) Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochemical Research. 34(8):1393–1400.
27. Zheng Wu, Qi Xu, Ruo Bing Qian, Feng Yu, Lian Yu, DH Kong, Liecheng Wang. Temporal lobe epilepsy animal model established by stereotaxic microinjection of kainic acid. Neural Regen Res, 2008, 3: 436-440.
1.国家自然科学基金委员会，面上项目，82571603，重塑PV神经元活性改善阿尔茨海默症模型小鼠认知功能的研究，2026.01至2029.12，主持。
2.广东省卫生健康委员会，“珠江人才计划”青年拔尖人才项目，0920220219，2023.01至2025.12，主持。
3.广东省科技厅，“珠江人才计划”引进创新创业团队，2021ZT09Y552，2022.12至2027.11，第一核心成员，子课题负责人。
4.广东省科技厅，广东省自然科学基金面上项目，PV神经元活性失调在阿尔茨海默病认知障碍中的关键作用及靶向干预研究，2022A1515012294，2026.01至2028.12，主持。
5.广东省科技厅，广东省自然科学基金面上项目，bHLH家族转录因子Olig2对星形胶质细胞原位转分化的影响研究，2022A1515012294，2022.01至2024.12，主持。
6.广州市科技局，广州市重点研发计划，脑科学与类脑研究重大科技专项，大脑原位神经再生技术在灵长类脑疾病模型中的应用与机制研究，202206060002，2022.04至2025.03，子课题负责人。
1. 一种用于啮齿类动物脑片电生理测试的样品孵育装置, 2024-05-24, 发明人：吴政; 雷文亮; 陈蓉杰。 中国, ZL 2023 2 2367223.9 （已授权）
2. Olig2 在星形胶质细胞转分化为功能性神经元中的应用，2024-12-13，发明人：吴政；陈功；赖楚莹；侯凯钰。中国，2024118354184 （已授权）。
3. cGAS-STING 通路抑制剂在减轻AAV 诱导的神经免疫反应中的应用，2025-12-01，发明人：吴政；郭耀威。中国，2025117846542
4. Generating GABAergic neurons in brains. Filed date: Feb.17, 2017. Date of Patent: Apr.13, 2021.USA. Inventor: Gong Chen, Ziyuan Guo, Zheng Wu, Zifei Pei, Yuchen Chen. Patent number: US10973930 B2
5. Reducing memory loss in mammals suffering from alzheimer's disease. Filed date: Jul. 3, 2018. Date of Patent: Oct.27, 2020.USA. Inventor: Gong Chen, Zheng Wu, Ziyuan Guo. Patent number: US10813922 B2
6. Methods and compositions for treatment of disease or injury of the nervous system. Filed date: Jul. 19, 2013. Date of patent: Feb.18,2020, Inventor: Gong Chen, Ziyuan Guo, Zheng Wu. Patent number: US10561742 B2.
7. Methods and materials for treating Huntington's disease, 2020-6-17, Inventor: Gong Chen, Zheng Wu, Ziyuan Guo, Yuchen Chen, Zifei Pei. WIPO, WO 2020/263639 A1.
8. Glucose oxidase compositions as a neonate anticonvulsant. Filed date: Jan. 03, 2018. Date of Patent: Feb.26, 2019.USA. Inventor: Gong Chen, Zheng Wu. Patent number: US10213491 B2.
9. Gluconate-based compositions as a neonate anticonvulsant. Filed date: May 16, 2016. Date of Patent: Jan.9, 2018.USA. Inventor: Gong Chen, Zheng Wu. Patent number: US9861597 B2.
10. Regenerating functional neurons for treatment of disease and injury in the nervous system. Filed date: Jul. 19, 2013. Date of Patent: Aug.1, 2017.USA. Inventor: Gong Chen, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, Ziyuan Guo. Patent number: US9717804 B2.
11. Regenerating functional neurons for treatment of disease and injury in the nervous system. Filed date: Jul. 6, 2017. Date of Patent: Feb.12, 2019.USA. Inventor: Gong Chen, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, Ziyuan Guo. Patent number: US10201619 B2. This patent has more claims than number 3 patent.
12. Reducing memory loss in mammals suffering from alzheimer's disease. Filed date: Jul. 15, 2014. Date of Patent: Aug.7, 2018.USA. Inventor: Gong Chen, Zheng Wu, Ziyuan Guo. Patent number: US10039756 B2.
