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姜志宏

姜志宏客座教授

职称：客座教授

研究方向：天然药物化学 代谢组学 生物有机化学 中药质量标准

Email：zhjiang@must.edu.mo

  • 个人简介
  • 教育背景
  • 研究方向
  • 专利著作

个人简介


姜志宏教授于1987年毕业于中国药科大学，1990年于同校取得硕士学位。1994年获日本国费奖学金资助留学日本， 1998年在长崎大学获得药学博士学位。 1999年至2001年间在美国哈佛医学院生物化学与分子药理学系进行博士后研究工作，从事抗肿瘤抗生素与小RNA形成共价键附加物的研究。2001年姜志宏博士受聘于香港浸会大学中医药学院任助理教授，2005年提升为副教授，2008年任教授。2011年7月任澳门科技大学澳门药物及健康应用研究院院长，2016年3月任澳门科技大学副校长。2022年3月起兼任中药质量研究国家重点实验室（澳门科技大学）主任，2024年12月兼任国家工信部国家分子药物创新中心主任。


姜教授是国际知名的天然药物化学家， 他的研究领域包括天然药物化学、 代谢组学、中药质量标准以及生物有机化学。为了推进中药现代化，姜教授一直潜心以现代光谱和色谱学、化学生物学和代谢组学的研究技术阐明中药的有效成分和作用机理，并取得卓著成果。迄今姜教授已在Nucleic Acids Research, Nature Communications, JACS, Analytical Chemistry, Organic Letters, Molecular Therapy-Nucleic Acids等国际学术刊物上发表330余篇SCI论文，引用次数达14,000余次，H-index为68 (Google Scholar, 2025)。姜教授于2007年获得国家杰出青年基金（海外），并于2014年获聘为国家教育部长江学者讲座教授，2022年当选为国家药典委员会委员。他的研究亦得到澳门科学技术发展基金、香港研究资助局、香港卫生署、国家自然科学基金、美国国立卫生研究院的资助。此外，姜教授还担任全国中药标准化技术委员会副主任委员、海峡两岸暨港澳地区中医药科技合作中心会长、澳门科协副会长、澳门特区政府科技委员会和经济委员会委员，以及澳门高等教育发展促进会副理事长等社会职务。近几年，姜教授一直专注于中医药tRNA来源的siRNA新药研究， 以及tRNA修饰在癌症和药物耐药中的作用。 他是首位从tRNA修饰的角度阐明紫杉醇耐药机制的科学家， 也是首位提出tRNA及其片段是中药材活性成分的观点。


姜教授拥有60多项中国和国际专利，其中关于中药tRNA来源的siRNA的几项专利已成功转让给澳门和香港的两家制药公司。

1998年3月


日本长崎大学药学 博士学位


1990年7月


中国药科大学理学 硕士学位


1987年7月


中国药科大学理学 学士学位


主要研究

姜教授研究领域包括天然药物化学、 代谢组学、中药质量标准以及生物有机化学。为了推进中药现代化，他以现代光谱和色谱学、化学生物学和代谢组学的研究技术阐明中药的有效成分和作用机理，并取得卓著成果。


发表论著

  1. Yanqi Wu, Yuhong Guan, Peilin Huang, Hui Chen, Liping Bai, Zhihong Jiang*. "Preparation of norovirus GII loop mediated isothermal amplification freeze-drying microsphere reagents and its application in an on-site integrated rapid detection platform." Chinese Chemical Letters 35.9 (2024): 109308.

  2. Lu Fu, Can-Can Wang, Wenyue Tian, Zhiyan Liu, Meng-Yu Bao, Jiazheng Liu, Wei Zhang, Li-Ping Bai*, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "NMR-Guided Isolation of Anti-inflammatory Carabranolides from the Fruits of Carpesium abrotanoides L." Journal of Natural Products 87.7 (2024): 1786-1797.

  3. Jiazheng Liu, Ting Xu, Jianjun Ding, Haoyue Wen, Jieru Meng, Qing Liu, Xiaomei Liu, Wei Zhang, Guo-Yuan Zhu, Zhi-Hong Jiang*, Jin Gao*, Li-Ping Bai*. "Discovery of anti-melanogenic components in persimmon (Diospyros kaki) leaf using LC-MS/MS-MN, AlphaFold2-enabled virtual screening and biological validation." Food Chemistry (2024): 139814.

  4. Liu Yang, Chengting Zi, Yanlang Li, Jia Huang, Zhijia Gu, Caiyun Wang, Jiang-Miao Hu*, Zhihong Jiang*, Wei Zhang*. "An in-depth investigation of molecular interaction in zeaxanthin/corn silk glycan complexes and its positive role in hypoglycemic activity." Food Chemistry 438 (2024): 137986.

  5. Zhi-Rong Lin, Meng-Yu Bao, Hao-Ming Xiong, Dai Cao, Li-Ping Bai, Wei Zhang, Cheng-Yu Chen, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Boswellianols A–I, Structurally Diverse Diterpenoids from the Oleo-Gum Resin of Boswellia carterii and Their TGF-β Inhibition Activity." Plants 13.8 (2024): 1074.

  6. Lu Fu, Wenyue Tian, Meng-Yu Bao, Zhiyan Liu, Wen-Jing Ren, Jiazheng Liu, Wei Zhang, Zhifeng Zhang, Jin Gao, Li-Ping Bai*, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Cevanine-type alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their antifibrotic activities in vitro." Phytochemistry 220 (2024): 114018.

  7. Ling Zeng, Cangman Zhang, Mingrong Yang, Jianfeng Sun, Jingguang Lu, Huixia Zhang, Jianfeng Qin, Wei Zhang, Zhihong Jiang*. "Unveiling the Diversity and Modifications of Short Peptides in Buthus martensii Scorpion Venom through Liquid Chromatography-High Resolution Mass Spectrometry." Toxins 16.3 (2024): 155.

  8. Fei-Long Chen, Dong-Li Liu, Wen-Jing Ren, Hao-Ming Xiong, Li-Ping Bai, Wei Zhang, Chitin Hon, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Atrachinenins D–S, novel meroterpenoids with geranyl hydroquinone moiety from Atractylodes chinensis by the LC/MS-based molecular decoy and targeted isolation." Bioorganic Chemistry 144 (2024): 107111.

  9. Peilun Lyu, Jiazheng Liu, Yuhan Zhang, Ben Ye, Ting Lan, Li-Ping Bai, Zhanchuan Cai*, Zhi-Hong Jiang*. "A Novel Feature Fusion Framework for Industrial Automation Single-Multiple Object Detection." IEEE Transactions on Industrial Informatics 20.5 (2024): 7686-7697.

  10. Min Zhang, Long-Bo Bai, Lee-Fong Yau, Tian-Tian Tong, Wei Zhang*, Zhi-Hong Jiang*. "Identification of Cannabidivarin Metabolites in Different Mouse Organs Using Ultra-Performance Liquid Chromatography Coupled to a Quadrupole Time-of-Flight Mass Spectrometer." Cannabis and Cannabinoid Research 9.1 (2024): 386-396.

  11. Yue Wang, Fei Yu, Qinghua Liu, Caiyun Wang, Guoyuan Zhu, Liping Bai, Shuai Shi, Yunfeng Zhao*, Zhihong Jiang*, Wei Zhang*. "A novel and sensitive dual signaling ratiometric electrochemical aptasensor based on nanoporous gold for determination of Ochratoxin A." Food Chemistry 432 (2024): 137192.

  12. Xinyu Zhang, Yuting Chen, Yueying Pan, Xinye Ma, Gui Hu, Song Li, Yan Deng, Zhu Chen, Hui Chen*, Yanqi Wu*, Zhihong Jiang*, Zhiyang Li. "Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection." Chinese Chemical Letters 35.1 (2024): 108378.

  13. Da Zhang, Lee-Fong Yau, Long-Bo Bai, Tian-Tian Tong, Kai-Yue Cao, Tong-Meng Yan, Ling Zeng, Zhi-Hong Jiang*. "Hydroxyapatite-based nano-drug delivery system for nicotinamide mononucleotide (NMN): significantly enhancing NMN bioavailability and replenishing in vivo nicotinamide adenine dinucleotide (NAD+) levels." Journal of Pharmacy and Pharmacology 75.12 (2023): 1569-1580.

  14. Mingyue Zhou, Ziwei Yang, Tianpeng Yin, Yunfeng Zhao, Cai-yun Wang, Guo-yuan Zhu, Li-ping Bai, Zhi-hong Jiang*, Wei Zhang*. "Functionalized Fe-Doped Carbon Dots Exhibiting Dual Glutathione Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy." ACS Applied Materials & Interfaces 15.46 (2023): 53228-53241.

  15. Qian-Bao Liu, Jiazheng Liu, Jing-Guang Lu, Ming-Rong Yang, Wei Zhang, Wen-Jia Li, Zheng-Ming Qian, Zhi-Hong Jiang*, Li-Ping Bai*. "Quantitative 1H NMR with global spectral deconvolution approach for quality assessment of natural and cultured Cordyceps sinensis." Journal of Pharmaceutical and Biomedical Analysis (2023): 115603.

  16. Yingwei Wang, Mingrong Yang, Chichou Lao, Hanxuan Wang, Zhihong Jiang*. "Oxidative Cross-Coupling of α-Amino Ketones with Alcohols Enabled by I2-Catalyzed C–H Hydroxylation." The Journal of Organic Chemistry 88.20 (2023): 14470-14486.

  17. Hao-Yuan Lyu, Meng-Yu Bao, Chi-Cheng Io, Hao-Ming Xiong, Fei-Long Chen, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Sesquiterpenoids from the roots of Aucklandia costus and their anti-inflammatory activities." Fitoterapia (2023): 105604.

  18. Raoqiong Wang, Guoxin Huang, Shuangyang Li, Hanlin Huang, Guoyuan Zhu, Liang Wang, Jinrui Yang, Sijin Yang*, Zhihong Jiang*, Wei Zhang*. "Blueberry extract for the treatment of ischaemic stroke through regulating the gut microbiota and kynurenine metabolism." Phytotherapy Research 38 (2023): 4792–4814..

  19. Hui-Xia Zhang, Dian Yu, Jian-Feng Sun, Ling Zeng, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang*, Wei Zhang*. "An integrated approach to evaluate acetamiprid-induced oxidative damage to tRNA in human cells based on oxidized nucleotide and tRNA profiling." Environment International (2023): 108038.

  20. Hao-Ming Xiong, Hui-Ying Li, Zhi-Rong Lin, Xiao-Mei Liu, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Chemical Constituents from the Fruits of Amomum kravanh and Their Role in Activating Alcohol Dehydrogenase." Molecules 28.12 (2023): 4878.

  21. Fei Ren, Kai-Yue Cao, Rui-Ze Gong, Meng-Lan Yu, Peng Tao, Yi Xiao, Zhi-Hong Jiang*. "The role of post-transcriptional modification on a new tRNAIle (GAU) identified from Ganoderma lucidum in its fragments’ cytotoxicity on cancer cells." International Journal of Biological Macromolecules 229 (2023): 885-895.

  22. Hui-Xia Zhang, Jian-Feng Qin, Jian-Feng Sun, Yu Pan, Tong-Meng Yan, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang*, Wei Zhang*. "Selective Chemical Labeling Strategy for Oligonucleotides Determination: A First Application to Full-Range Profiling of Transfer RNA Modifications." Analytical Chemistry 95.2 (2023): 686-694.

  23. Jie-Ru Meng, Jiazheng Liu, Lu Fu, Tong Shu, Lingzhi Yang, Xueji Zhang, Zhi-Hong Jiang*, Li-Ping Bai*. "Anti-entry activity of natural flavonoids against SARS-CoV-2 by targeting spike RBD." Viruses 15.1 (2023): 160.

  24. Tianpeng Yin, Yi Yu, Qinghua Liu, Guoyuan Zhu, Liping Bai, Wei Zhang*, Zhihong Jiang*. "13C-NMR-based MixONat strategy coupled with 2D NMR for rapid dereplication and identification of new secondary metabolites from Aloe vera." Journal of Food Composition and Analysis 115 (2023): 104975.

  25. Hui Chen, Xinye Ma, Xinyu Zhang, Gui Hu, Yan Deng, Song Li, Zhu Chen, Nongyue He*, Yanqi Wu*, Zhihong Jiang*. "Novel aerosol detection platform for SARS- CoV- 2: Based on specific magnetic nanoparticles adsorption sampling and digital droplet PCR detection." Chinese Chemical Letters 34.1 (2023): 107701.

  26. Lee-Fong Yau, Hao Huang, Tian-Tian Tong, Long-Bo Bai, Guo-Yuan Zhu, Yuanyuan Hou, Gang Bai*, Zhi-Hong Jiang*. "Characterization of deglycosylated metabolites of platycosides reveals their biotransformation after oral administration." Food Chemistry 393 (2022): 133383.

  27. Xu-Jia Wu, Dai Cao, Fei-Long Chen, Rong-Sheng Shen, Jin Gao, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro [4, 2, 5, 2] pentadecane-6, 10, 14-tren Moiety from Chloranthus fortunei." ACS Omega 7.39 (2022): 35063-35068.

  28. Jiazheng Liu, Jieru Meng, Runfeng Li, Haiming Jiang, Lu Fu, Ting Xu, Guo-Yuan Zhu, Wei Zhang, Jin Gao, Zhi-Hong Jiang*, Zi-Feng Yang*, Li-Ping Bai*. "Integrated network pharmacology analysis, molecular docking, LC-MS analysis and bioassays revealed the potential active ingredients and underlying mechanism of Scutellariae radix for COVID-19." Frontiers in plant science 13 (2022): 988655.

  29. Tian‐Peng Yin, Yi Yu, Qing‐Hua Liu, Ming‐Yue Zhou, Guo‐Yuan Zhu, Li‐Ping Bai, Wei Zhang*, Zhi‐Hong Jiang*. "2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids." Chinese Journal of Chemistry 40.18 (2022): 2169-2178.

  30. Kua Hu, Tong-Meng Yan, Kai-Yue Cao, Fang Li, Xiao-Rong Ma, Qiong Lai, Jin-Cheng Liu, Yu Pan, Jun-Ping Kou, Zhi-Hong Jiang*. "A tRNA-derived fragment of ginseng protects heart against ischemia/reperfusion injury via targeting the lncRNA MIAT/VEGFA pathway." Molecular Therapy-Nucleic Acids 29 (2022): 672-688.

  31. Jing-Guang Lu, Yingwei Wang, Ming-Rong Yang, Cai-Yun Wang, Jieru Meng, Jiazheng Liu, Zifeng Yang, Kongsong Wu, Li-Ping Bai*, Guo-Yuan Zhu*, Zhi-Hong Jiang*. "Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens." Archives of Pharmacal Research 45.9 (2022): 631-643.

  32. Long‐Bo Bai, Lee‐Fong Yau, Tian‐Tian Tong, Wai‐Him Chan, Wei Zhang*, Zhi‐ Hong Jiang*. "Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol." Pharmacology Research & Perspectives 10.4 (2022): e00986.

  33. Rong-Sheng Shen, Dai Cao, Fei-Long Chen, Xu-Jia Wu, Jin Gao, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "New Monoterpene-Conjugated Phenolic Constituents from Nutmeg and Their Autophagy Modulating Activities." Journal of Agricultural and Food Chemistry 70.31 (2022): 9684-9693.

  34. Kai-Yue Cao, Yu Pan, Tong-Meng Yan, Peng Tao, Yi Xiao, Zhi-Hong Jiang*. "Antitumor activities of tRNA-derived fragments and tRNA halves from non-pathogenic Escherichia coli strains on colorectal cancer and their structure-activity relationship." mSystems 7.2 (2022): e00164-22.

  35. Yingwei Wang, Mingrong Yang, Chichou Lao, Zhihong Jiang*. "Potassium-Base-Mediated Autoxidative Diastereoselective Homocoupling of N-Acyl-2-aminoacetophenones." Organic Letters 24.14 (2022): 2625-2629.

  36. Kai-Yue Cao, Tong-Meng Yan, Ji-Zhou Zhang, Ting-Fung Chan, Jie Li, Chong Li, Elaine Lai-Han Leung, Jin Gao, Bao-Xian Zhang, Zhi-Hong Jiang*. "A tRNA-derived fragment from Chinese yew suppresses ovarian cancer growth via targeting TRPA1." Molecular Therapy-Nucleic Acids 27 (2022): 718-732.

  37. Fei‐Long Chen, Dong‐Li Liu, Jing Fu, Ji Yang, Li‐Ping Bai, Wei Zhang, Zhi‐Hong Jiang*, Guo‐Yuan Zhu*. "(±)‐Atrachinenins A—C, Three Pairs of Caged C27 Meroterpenoids from the Rhizomes of Atractylodes chinensis." Chinese Journal of Chemistry 40.4 (2022): 460-466.

  38. Fei-Long Chen, Dong-Li Liu, Jing Fu, Lu Fu, Jin Gao, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Atrachinenynes A–D, four diacetylenic derivatives with unprecedented skeletons from the rhizomes of Atractylodes chinensis." New Journal of Chemistry 46.32 (2022): 15530-15537.

  39. Tianpeng Yin, Jingguang Lu, Qinghua Liu, Guoyuan Zhu, Wei Zhang*, Zhihong Jiang*. "Validated quantitative 1H NMR method for simultaneous quantification of indole alkaloids in Uncaria rhynchophylla." ACS Omega 6.47 (2021): 31810-31817.

  40. Xin Liu, Jing Fu, Rong-Sheng Shen, Xu-Jia Wu, Ji Yang, Li-Ping Bai, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Linderanoids A–O, dimeric sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm." Phytochemistry 191 (2021): 112924.

  41. Yahui Ge, Na Li, Yu Fu, Xi Yu, Ying Xiao, Zhiying Tang, Jianbo Xiao, Jian-Lin Wu*, Zhi-Hong Jiang*. "Deciphering superior quality of Pu-erh tea from thousands of years’ old trees based on the chemical profile." Food Chemistry 358 (2021): 129602.

  42. Qiang Shang, Xiaobo Zhou, Ming-Rong Yang, Jing-Guang Lu, Yu Pan, Guo-Yuan Zhu*, Zhi-Hong Jiang*. "Amide Derivatives of Ginkgolide B and Their Inhibitory Effects on PAF-Induced Platelet Aggregation." ACS Omega 6.35 (2021): 22497-22503.

  43. Xin Liu, Ji Yang, Jing Fu, Pei-Lin Xu, Tang-Gui Xie, Li-Ping Bai, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Monoterpene-flavonoid conjugates from Sarcandra glabra and their autophagy modulating activities." Bioorganic Chemistry 112 (2021): 104830.

  44. WANG Cai-Yun, LU Jing-Guang, CHEN Da-Xin, WANG Jing-Rong, CHE Kai-Si, Ming Zhong, Wei Zhang*, Zhi-Hong Jiang*. "Comprehensive chemical study on different organs of cultivated and wild Sarcandra glabra using ultra-high performance liquid chromatography time-of-flight mass spectrometry (UHPLC-TOF-MS)." Chinese Journal of Natural Medicines 19.5 (2021): 391-400.

  45. Xin Liu, Jing Fu, Ji Yang, Ancheng C Huang, Run-Feng Li, Li-Ping Bai, Liang Liu, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Linderaggrenolides A–N, oxygen-conjugated sesquiterpenoid dimers from the roots of Lindera aggregata." ACS Omega 6.8 (2021): 5898-5909.

  46. Yu Pan, Tong-Meng Yan, Jing-Rong Wang, Zhi-Hong Jiang*. "The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance." Nucleic Acids Research 49.1 (2021): 38-52.

  47. Run-Feng Li, Xiao-Bo Zhou, Hong-Xia Zhou, Zi-Feng Yang, Hai-Ming Jiang, Xiao Wu, Wen-Jia Li, Jian-Jian Qiu, Jia-Ning Mi, Ming Chen, Nan-Shan Zhong, Guo-Yuan Zhu*, Zhi-Hong Jiang*. "Novel fatty acid in Cordyceps suppresses influenza A (H1N1) virus-induced proinflammatory response through regulating innate signaling pathways." ACS Omega 6.2 (2021): 1505-1515.

  48. Tianpeng Yin, Huixia Zhang, Wei Zhang*, Zhihong Jiang*. "Chemistry and biological activities of hetisine-type diterpenoid alkaloids." RSC advances 11.57 (2021): 36023-36033.

  49. Yingwei Wang, Mingrong Yang, Chichou Lao, Zhihong Jiang*. "C–H bond cleavage-enabled aerobic ring-opening reaction of in situ formed 2-aminobenzofuran-3 (2 H)-ones." Organic & Biomolecular Chemistry 19.43 (2021): 9448-9459.

  50. Ji Yang, Xin Liu, Jing Fu, Hao-Yuan Lyu, Li-Ping Bai, Zhi-Hong Jiang*, Guo-Yuan Zhu*. "Calycindaphines A–J, Daphniphyllum alkaloids from the roots of Daphniphyllum calycinum." RSC Advances 11.16 (2021): 9057-9066.


专利

  1. 专利名称:灵芝 tRFs 在哮喘治疗中的制药用途;授权年份:2024;专利号:CN
    114504591B;发明人:姜志宏、马元、任飞。

  2. 专利名称:异喹啉生物碱化合物及其制备和用途;授权年份:2023;专利号: CN113620952B;发明人:姜志宏、卢敬光、杨明蓉、朱国元、白丽萍、王应伟、 马晓蓉、孟洁茹、胡姱;

  3. 专利名称:用于提高 NAD+水平的组合物及其用途;授权年份:2023;专利号: CN113712987B;发明人:姜志宏、佟天天、白隆博、丘利芳。

  4. 专利名称:金色酰胺醇酯及其氟化衍生物及制备方法和应用;授权年份:2023;专 利号: CN112500308B;发明人:姜志宏、钟南山、杨子峰、王静蓉、冯启童、周 小波、周倍贤。

  5. 专利名称:具有抗 SARS-CoV-2 病毒作用的口鼻用药物组合物及其制备方法;授权 年份:2023;专利号:CN114796435B;发明人:王静蓉、姜志宏、余琼希、丘利 芳、杨子峰、麦芷桐、王琳。

  6. 专利名称:一种含芦荟提取物的组合物及其应用;授权年份:2022;专利号: CN111773301B;发明人:张伟、姜志宏、李妍、杨紫薇、郭建茹、王彩云。

  7. 专利名称:用于治疗癌症的方法和药物组合物;授权年份:2021;专利号: CN110870871B;发明人:姜志宏、严通萌、曹凯悦。

  8. 专利名称:一种双链 RNA 分子及其用途;授权年份:2021;专利号 CN111763669B; 发明人:姜志宏、曹凯悦、潘聿、严通萌。

  9. 专利名称:转运 RNA 分子及其片段用于预防或治疗心脏疾病的用途;授权年份: 2021;专利号:CN111419867B;发明人:姜志宏、胡姱、严通萌;

  10. 专利名称:包含非编码 RNA 分子和靶向肿瘤抗原的抗体的药物组合物;授权年份: 2021;专利号:CN112089835B;发明人:姜志宏、丘利芳、佟天天、黄浩、胡姱、 梁丽娴。

  11. 专利名称:一种冬虫夏草的成分分析方法与应用;授权年份:2021;专利号: CN112595771B;发明人:姜志宏、白丽萍、卢敬光、刘倩宝、杨子峰、钟南山。

  12. 专利名称:(2Z,4E)-2,4-癸二烯酸在制备用于治疗流感病毒引起的炎症的药物方面的 应用;授权年份:2021;专利号: CN111743888B;发明人:杨子峰、姜志宏、李 润峰、周小波。

  13. 专利名称:一种强心苷类化合物及其合成方法与应用;授权年份:2021;专利号: CN112194703B;发明人:白丽萍、郑植元、周小波、朱国元、姜志宏。

  14. 专利名称:MEDICINAL COMPOSITION COMPRISING A NONCODING RNA MOLECULE AND AN ANTIBODY TARGETING A TUMOR ANTIGEN;授权年份: 2024;专利号:US11944636B2;发明人:Zhi-Hong Jiang，Lee-Fong Yau，Tian-Tian Tong，Hao Huang，Kua Hu，Elaine Lai-Han Leung

  15. 专利名称:NUCLEIC ACID MOLECULES AND USES THEREOF ;授权年份:2024; 专利号:US11866704B2;发明人:Zhi-Hong Jiang，Kai-Yue Cao，Yu Pan，Tong-Meng Yan.

  16. 专 利 名 称 : METHOD AND COMPOUNDS FOR INHIBITING THE MCM COMPLEX AND THEIR APPLICATION IN CANCER TREATMENT ;授权年份: 2023;专利号:US11648258B2;发明人:Chun Liang，Zhi-Hong Jiang，Ziyi Wang， Zhiling Yu，Jingrong Wang，Liping Bai.

  17. 专利名称: COMPOUNDS AND METHODS FOR TREATING INFLUENZA ;授权 年份:2022;专利号:US11377418B2;发明人: Zhi-Hong Jiang，Nanshan Zhong， Zifeng Yang，Jingrong Wang，Qitong Feng，Xiaobo Zhou，Beixian Zhou.

  18. 专利名称: METHOD OF ISOLATING SPHINGOLIPIDS FROM CORDYCEPS AND THEIR USE ;授权年份:2022;专利号:US11357806B2;发明人: Zhi-Hong Jiang， Jingrong Wang，Mijia Ning，Junping Kou，Yuwei Han，Yingqiong Xu.

  19. 专利名称:METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER;授权年份:2021;专利号:US11149271B2;发明人:Zhi-Hong Jiang， Tong-Meng Yan，Kai-Yue Cao.

  20. 专利名称:USE OF GLYCANS AS BIOMARKERS FOR AUTOIMMUNE DISEASES; 授权年份:2021;专利号:US10900966B2;发明人:Liang Liu, Jingrong Wang， Weina Gao，Leefong Yau，Hao Huang，Qiong Meng, Tiantian Tong，Zhi-Hong Jiang.


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