职称：杰出访问教授
研究方向：Vidal-Puig 对四个研究领域的具体科学贡献：1）定义脂肪组织扩张性和脂毒性假说；2）提议使用能量耗散策略通过促进线粒体生物发生、线粒体解偶联和棕色脂肪分化和激活来逆转脂毒性； 3) 确定下丘脑脂质代谢与控制能量稳态和甲状腺激素以及BMP8b控制棕色脂肪活化的相关性；4) 开创性地使用系统生物学和干细胞方法阐明特定脂质和网络在心脏代谢综合征发展中的作用。
Email：ajv22@medschl.cam.ac.uk
Antonio Vidal-Puig 教授为剑桥大学代谢研究所教授，致力于探索机体控制能量消耗、脂肪沉积以及控制能量氧化或储存的机制。Antonio Vidal-Puig带领团队一直在进行脂肪组织的扩张与代谢综合征的发生发展过程中的关系进行研究，切入脂肪组织分泌的脂肪毒性和/或脂肪因子的变化是否会影响骨骼肌、心脏、肝脏、大脑、β-细胞和巨噬细胞等其他器官对胰岛素的敏感性，脂肪生成和脂肪组织重塑的改变是否可能成为改善与肥胖相关的代谢影响的关键因素，以及控制能量消耗和棕色脂肪激活的分子机制等进行探索。在Nature Medicine, Cell, Cell Metab 等杂志发表SCI论文280余篇，被引用46,400余次，H指数= 114。
Toh Chin Chye visiting professorship National University of Singapore.
Honorary Doctorate University Rey Juan Carlos Madrid.
Executive Master Business Administration (EMBA). Judge Institute Business School.
University of Cambridge
Fellow Academy of Medical Sciences (FMedSci)
Fellow Royal College of Physicians (FRCP)
Endocrinology, Metabolism, Nutrition Specialist, Spanish Ministry of Health
Ph.D. degree. Granada University School of Medicine, Granada, Spain.
M.D. degree. Valencia University School of Medicine Valencia, Spain. Magna Cum Laude
Vidal-Puig （TVPLab， http://tvp.mrl.ims.cam.ac.uk/） 的研究阐明了肥胖与胰岛素抵抗、糖尿病和心脏代谢并发症之间的分子机制，以及相关治疗策略的开发。他的研究策略包括假设驱动和非偏倚系统方法的组合，广泛使用动物模型、干细胞生物学、人类生物样本（包括诱导多能干细胞）、复杂的组学技术和生物信息学整合。
Vidal-Puig’s (TVPLab, http://tvp.mrl.ims.cam.ac.uk/) research elucidates the molecular mechanisms linking obesity with insulin resistance, diabetes and cardiometabolic complications
and on the development of related therapeutic strategies. His research strategies include a
combination of hypothesis-driven and non-biased systems approaches that extensively use
animal models, stem cell biology, human biological samples (including induced pluripotent stem
cells), sophisticated omics technologies and bioinformatics integration.
Vidal-Puig 的实验室创造力体现在“脂肪组织扩张性假说”和“脂毒性”的概念中，以解释肥胖与心脏代谢并发症之间的关联。他对四个研究领域的具体科学贡献是：1） 定义脂肪组织膨胀性和脂毒性假说 （Vidal-Puig， JCI 1996 （Cit 513）， 1997 （Cit 766）;PLoS 遗传学 2007 （cit 211）;2） 提议使用能量耗散策略通过促进线粒体生物发生（PLoS Biol 等人 2006，Cit 198）、线粒体解偶联（BBRC 1997，Cit 710，JBC 2000 Cit 639）和棕色脂肪分化和激活来逆转脂毒性（Cell 2012，Cit 160）;3） 确定下丘脑脂质代谢在控制能量稳态 （Cell Metab 2008， Cit 277）） 和甲状腺激素 （Nature Medicine， 2010， Cit 266） 和 BMP8b 控制棕色脂肪活化 （Cell 2012） 中的相关性;4） 率先使用系统生物学和干细胞方法来阐明特定脂质和网络在心脏代谢代谢综合征发展中的作用。
Vidal-Puig’s lab creativity is reflected in the “adipose tissue expandability hypothesis” and the
concept of “lipotoxicity” to explain the association between obesity and cardiometabolic
complications. His specific scientific contributions to four lines of research are: 1) defining the
adipose tissue expandability and lipotoxicity hypothesis (Vidal-Puig, JCI 1996 (Cit 513), 1997 (Cit 766); PLoS Genetics 2007 (Cit 211); 2) proposing the use of energy dissipating strategies to
reverse lipotoxicity by promoting mitochondrial biogenesis (PLoS Biol et al 2006, Cit 198),
mitochondrial uncoupling (BBRC 1997, Cit 710, JBC 2000 Cit 639)) and brown fat differentiation
and activation (Cell 2012, Cit 160); 3) establishing the relevance of hypothalamic lipid
metabolism in controlling energy homeostasis (Cell Metab 2008, Cit 277)) and thyroid hormone
(Nature Medicine, 2010, Cit 266) and BMP8b controlling brown fat activation (Cell 2012); and 4)
the pioneering use of systems biology and stem cell approaches to elucidate the role of specific
lipids and networks in the development the cardiometabolic metabolic syndrome.
1. I Kamzolas, M Vacca, L Mørch Harder, S Rodriguez-Cuenca, L Tiniakos, ... A Vidal-Puig. An unbiased ranking of murine dietary models based on their proximity to human Metabolic Dysfunction–associated Steatotic Liver Disease (MASLD). Nat Metab (in press)
2. SM Oussaada, M Kilicarslan, BA de Weijer, PW Gilijamse, A Şekercan, S Virtue, IMC Janssen, A van de Laar, A Demirkiran, BA van Wagensveld, APJ Houdijk, A Jongejan, PD Moerland, J Verheij, TB Geijtenbeek, VW Bloks, MC de Goffau, JA Romijn, M Nieuwdorp, A Vidal-Puig, KW Ter Horst, MJ Serlie. Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Research and Clinical Practice (in press)
3. Tan J, Virtue S, Norris DM, Conway OJ, Yang M, Bidault G, Gribben C, Lugtu F, Kamzolas I, Krycer JR, Mills RJ, Liang L, Pereira C, Dale M, Shun-Shion AS, Baird HJ, Horscroft JA, Sowton AP, Ma M, Carobbio S, Petsalaki E, Murray AJ, Gershlick DC, Nathan JA, Hudson JE, Vallier L, Fisher-Wellman KH, Frezza C, Vidal-Puig A*, Fazakerley DJ. Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. EMBO J. 2024 Apr 5. doi: 10.1038/s44318-024-00084-7. PMID: 38580776
4. Ng MY, Song ZJ, Venkatesan G, Rodriguez-Cuenca S, West JA, Yang S, Tan CH, Ho PC, Griffin JL, Vidal-Puig A, Bassetto M, Hagen T. Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation. T. Sci Rep. 2024 Feb 28;14(1):4932. doi: 10.1038/s41598-024-54466-2. PMID: 38418847
5. Yu Y, Yang J, Zheng L, Su H, Cao S, Jiang X, Liu X, Liu W, Wang Z, Meng F, Xu H, Wen D, Sun C, Song X, Vidal-Puig A, Cao L. Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline. Mol Metab. 2024 Mar;81:101892. doi: 10.1016/j.molmet.2024.101892. PMID: 38331318
6. Xu J, Cui L, Wang J, Zheng S, Zhang H, Ke S, Cao X, Shi Y, Li J, Zen K, Vidal-Puig A*, Zhang CY, Li L, Jiang X. Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice. Nat Commun. 2023 Sep 6;14(1):5480. doi: 10.1038/s41467-023-41160-6. PMID: 37673898
7. Soria-Gondek A, Fernández-García P, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Pellitero S, Tarascó J, Jenkins B, Galán M, Villarroya F, Koulman A, Corrales P, Vidal-Puig A, Cereijo R, Sánchez-Infantes D. Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study. Nutrients. 2023 Jul 27;15(15):3341. doi: 10.3390/nu15153341. PMID: 37571279
8. Pellegrinelli V, Figueroa-Juárez E, Samuelson I, U-Din M, Rodriguez-Fdez S, Virtue S, Leggat J, Çubuk C, Peirce VJ, Niemi T, Campbell M, Rodriguez-Cuenca S, Blázquez JD, Carobbio S, Virtanen KA, Vidal-Puig A*. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Rep. 2023 Jun 13;42(6):112640. doi: 10.1016/j.celrep.2023.112640. PMID: 37318951
9. Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators. Lancet Gastroenterol Hepatol. 2023 Jun 5:S2468-1253(23)00141-3. doi: 10.1016/S2468- 1253(23)00141-3. Online ahead of print. PMID: 37290471
10. Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning. iScience. 2023 May 9;26(6):106847. doi: 10.1016/j.isci.2023.106847. eCollection 2023 Jun 16. PMID: 37250773
11. Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C. Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis. Mol Metab. 2023 Apr 28;73:101731. doi: 10.1016/j.molmet.2023.101731. Online ahead of print. PMID: 37121509
12. Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M. Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL). Mol Metab. 2023 Apr 19;73:101728. doi: 10.1016/j.molmet.2023.101728. Online ahead of print.PMID: 37084865
13. Lee J, Westphal M, Vali Y, Boursier J, Ostroff R, Alexander L, Chen Y, Fournier C, Geier A, Francque S, Wonders K, Tiniakos D, Bedossa P, Allison M, Papatheodoridis G, Cortez-Pinto H, Pais R, Dufour JF, Leeming DJ, Harrison S, Cobbold J, Holleboom AG, Yki-Järvinen H, Crespo J, Ekstedt M, Aithal GP, Bugianesi E, Romero-Gomez M, Karsdal M, Yunis C, Schattenberg JM, Schuppan D, Ratziu V, Brass C, Duffin K, Zwinderman K, Pavlides M, Anstee QM, Bossuyt PM; LITMUS investigators. Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study. Hepatology. 2023 Mar 31. doi: 10.1097/HEP.0000000000000364. Online ahead of print.PMID: 36994719
14. Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A. Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons. Mol Cell. 2023 Mar 3:S1097-2765(23)00114-4. doi: 10.1016/j.molcel.2023.02.011. PMID: 36917981
15. Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S. CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells. Int J Mol Sci. 2023 Feb 8;24(4):3399. doi: 10.3390/ijms24043399. PMID: 36834818
16. Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešič M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. PMID:36065182
17. Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A. Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis. Autophagy. 2022 Aug 25:1-22. doi: 10.1080/15548627.2022.2111081. PMID:35947488
18. Li C, Feng Y, Fu Z, Deng J, Gu Y, Wang H, Wu X, Huang Z, Zhu Y, Liu Z, Huang M, Wang T, Hu S, Yao B, Zeng Y, Zhou CJ, Brown SDM, Liu Y, Vidal-Puig A, Dong Y, Xu Y. Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest. Cell Death Discov. 2022 Aug 2;8(1):345. doi: 10.1038/s41420-022-01139-6. PMID: 35918318 PMCID: PMC9345867
19. Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S. TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972. doi: 10.1038/s41467-022-31735-0.PMID: 35803934
20. Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y. Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway. iScience. 2022 Apr 18;25(5):104267. doi: 10.1016/j.isci.2022.104267. PMID:35521538 PMCID: PMC9062755
21. Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C. Vidal-Puig A. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nat Metab 4, 476–494 (2022). https://doi.org/10.1038/s42255-022-00561-5. PMID: 35478031
22. Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A. Dietary PUFA drives various systems-level changes in lipid metabolism. Mol Metab. 2022 Feb 9;101457. doi: 10.1016/j.molmet.2022.101457. PMID: 35150907
23. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473
24. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547
25. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler- Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575
26. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432
27. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Oresic M, Bjursell M, Bohlooly-Y M, Lindén D and Vidal-Puig, A. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID: 3436960
28. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno- Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599
29. Furse S, Williams HEL, Watkins AJ, Virtue S, Vidal-Puig A, Amarsi R, Charalambous M, Koulman A. A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies. Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s00216-021-03430- 4. PMID: 34254158 PMCID: PMC8318958
30. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lupșor-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yılmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645
31. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi:10.1016/j.jhep.2021.04.044. PMID: 33991635
32. Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas- Elvira JM, Ruiz JR. Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women. Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. PMID: 33858825
33. Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M. Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID: 33833312. PMCID: PMC8032793
34. Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts L. Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signalling axis. Nature Com 12:1-21, 2021. PMID:33772024
35. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223
36. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690
36. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690
